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Beyond these frontrunners, the pipeline is expanding: Novo Nordisk filed for FDA approval of CagriSema in 2025, the first once-weekly combination of GLP1 and amylin analogue

Nevertheless, the certainty of the effect size following the GRADE classification was very low. Conclusions In this systematic review and meta-analysis, we found that GLP-1 RAs significantly prolonged gastric emptying T by a mean of 74min, which could have implications for perioperative care

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