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However, like any medication, there is always a possibility of side effects or adverse reactions in some individuals

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But the preclinical evidence is striking enough that major research institutions are investing significant resources to investigate further

The importance of glucagon receptors in the kidney has been further explored in mice with kidney-specific glucagon receptor knockout (80)

In a 12-week study of 91 patients with chronic renal insufficiency, 37 patients with moderate renal insufficiency were randomized to JANUVIA 50 mg daily, while 14 patients with the same magnitude of renal impairment were randomized to placebo

In a study by Ye et al., the protective effects of Liraglutide on glomerular podocytes in obese mice by inhibiting the inflammatory factor Tumor necrosis factor (TNF)--mediated NF-B and MAPK pathway was examined [77]