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Kidney problems (kidney failure)

Existing diabetic retinopathy, especially moderate or worse stages Hemoglobin A1c above 10 percent before starting semaglutide A1c drops of more than 2 percentage points within three months Previous episodes of diabetic macular edema or retinal bleeding Long duration of diabetes, typically more than ten years Eye Symptoms to Watch For While Taking Semaglutide Vision that changes from day to day or even hour to hour often signals shifting fluid levels in your retina or temporary changes in your lens shape

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These combined effects lead to significant and sustained weight loss, making tirzepatide an effective therapy for obesity management