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Shabtai, Y

This issue has also been recently reviewed by De Block et

Nevertheless, some studies suggest that Ex-4 significantly stimulates hMSC proliferation in a dose- and time-dependent-manner, particularly at concentrations between 10 nM and 100 nM, as shown in cell viability assays 3-(4,5-dimethylthiazol-2-yl)5-(3-carboxymethoxyphenyl)2-(4-sulfophenyl)2 H-tetrazolium (MTS) and Cell Counting Kit-8 (CCK-8), as well as DNA analysis 5-ethynyl-2-deoxyuridin (EdU) incorporation and PicoGreen assay [14,15,16]

Compounds containing proline demonstrated notable anticancer activity, with an IC 50 of 24 nM (Figure 5) against the A549 cell line, compared to the standard drug fluorouracil (IC 50 = 11.13 M) (107)

It can occur in some cases, particularly if dry mouth or ketosis is present

Crucially, the researchers noted that participants had not yet reached a weight plateau when the study ended, suggesting the true long-term potential could be even higher