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It cooperates with signals originating from the mechanoreceptors of the gut that are generated by the distention of the gut and transmitted to the brain through vagal afferents

2019 Dec 9;24(24):4501

Mounjaro is approved for managing type 2 diabetes, whereas Zepbound is used for chronic weight management in adults either with obesity or those overweight with another weight-related health condition such as hypertension, high cholesterol, or diabetes

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Caroline Apovian, codirector of the Center for Weight Management and Wellness at Brigham and Women's Hospital, also worries that the press release announcing the trial results may understate how common severe nausea and vomiting were, because it does not specify how many patients dropped out specifically because of those effects

Interestingly, all of the factors discussed in this section (incretins, bile acids, amino acids, the microbiome and GH signalling) could act via both peripheral and CNS signalling