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2025;55:e302

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Clinical trials (STEP programme) have demonstrated that Wegovy can lead to significant weight losstypically 1015% of initial body weight over 68 weekswhen combined with lifestyle modifications, though individual responses vary

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For the primary endpoint at week 104, the authors report that in evoke, the mean CDR-SB change from baseline was 2.3 (SE 0.1) with semaglutide and 2.3 (0.1) with placebo, with an estimated between-group difference of 0.08 (95% CI 0.35 to 0.20
