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investigated the effects of GLP-1 RAs on [H 3 ]D-aspartate release in purified synaptosomes.Reference Rebosio, Balbi, Passalacqua, Ricciarelli and Fedele 43 Notably, KCl-induced depolarization was potentiated with GLP-1 RA treatment wherein there was a 37% and 43% increase in [H 3 ]D-aspartate release in the cortical and hippocampal synaptosomes, respectively.Reference Rebosio, Balbi, Passalacqua, Ricciarelli and Fedele 43 Administration of exendin-3, a GLP-1 receptor antagonist, and 2-5-dideoxyadenosine both inhibited the observed increased in [H 3 ]D-aspartate, suggesting that activation of GLP-1 receptors is associated with increased glutamatergic signaling

Meanwhile, GIP enhances your body's ability to process sugar and regulate insulin

Therefore, GLP-1 and GIP receptor agonists that can cross the BBB show promise as treatments for chronic neurodegenerative disorders

Some patients may benefit from over-the-counter antacids, though any additional medications should be discussed with a pharmacist or GP to ensure compatibility with existing treatments

Food and Drug Administration (FDA) for chronic weight management