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The most well-established microvascular diseases and disorders include diabetic microvascular complications, small cerebral vessel disease, renal microvascular disease, pulmonary microvascular disease, systemic autoimmune microvascular disorders, and hereditary microangiopathies [155,156,157,158]

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The COMBO-DN studya multinational, randomized, double-blind, parallel-group study in patients with diabetic peripheral neuropathic pain

The reasons, as Dr

10.1038/sj.bjp.0707305 49 EliasA

Supplementation should be guided by blood tests (serum ferritin, full blood count) as excessive iron can be harmful
