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Over a lifetime, patients treated with tirzepatide were projected to incur costs that were $41,688 lower per patient, while gaining an additional 0.506 QALYs compared with patients receiving semaglutide, thus indicating both longevity and improved quality of life in the model

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Decisions about temporarily holding tirzepatide during acute significant gastrointestinal illness should be made based on clinical judgment and the severity of symptoms

Cotadutide effectively lowered blood sugar levels and reduced weight in obese individuals and T2DM patients, increased insulin secretion, delayed gastric emptying, with the most common side effects being gastrointestinal symptoms (nausea and vomiting), which were dose-dependent [99,100]