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2 Department of Endocrinology, SANKO University Faculty of Medicine, Gaziantep, Turkey Correspondence: Nimet Ylmaz, Department of Gastroenterology, SANKO University Faculty of Medicine, Gaziantep, Turkey, Email [email protected] Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual GLP-1/GIP receptor agonists are highly effective agents for the treatment of type 2 diabetes and obesity

These trials have shown reductions in heart failure symptoms and physical limitations and greater improvement in exercise function and have led to growing interest in new ways to address HFpEF, a condition with limited guideline direct medication therapy compared to heart failure with reduced ejection fraction (HFrEF)

The drug retatrutide, which is in trials, is a triple hitter that targets GLP-1 plus glucagon plus GIP receptors, all at once

There were 93 events in the smaller GLP-1 group, compared with 88 events in the twice-as-big non-GLP-1 group, yielding a 0.2% vs