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The basal GLP-1 secretion in the low-glucose (0.1 mM) state was significantly inhibited by ESI-09, or ESI-09 with H-89, and was stimulated only by 007-AM, a selective EPAC activator (Fig
[DOI] [PubMed] [Google Scholar] 70.Pannacciulli N, Le DS, Salbe AD, et al

These include maintaining regular meal patterns despite reduced appetite, avoiding prolonged fasting, ensuring adequate sleep (79 hours nightly), and managing stress through relaxation techniques

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