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17) revealed no significant change in the PDQ-39 between the treatment group and the placebo group (MD = 1.78

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A total of 1961 adults with a body-mass index (BMI) of 30 or above (or 27 in individuals with at least one weight-related medical condition) and without diabetes were enrolled in the study

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Conclusion: Cinchonine, a potential oral small-molecule GLP-1R agonist, could reduce blood glucose and ameliorate NASH, providing a strategy for developing small-molecule GLP-1R agonists
