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Lack of long-term safety data There is no long-term safety data on compounded semaglutide, as the medication has not undergone clinical trials

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[50] However, it is important to note that fenfluramine, rimonabant and lorcaserin used very different molecular mechanisms (acting mainly on serotonin 2c receptors [51] in the hypothalamus [52] or CB1 receptors [53] ) from GLP1R, GIPR or GR agonists and likewise do not imply anything on the possible dangers of GLP1R, GIPR or GR agonists

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GLP-1 cardiovascular outcomes Multiple large-scale cardiovascular outcomes trials have demonstrated that GLP-1 agonists reduce the risk of major adverse cardiovascular events, including heart attack, stroke, and cardiovascular death

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