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In pancreatic -cells, PC2 cleaves proglucagon to yield mature glucagon (29 aa), glicentin-related pancreatic polypeptide (GRPP) and the major proglucagon fragment (MPGF)
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However, native GLP-1 has a very short half-life because it is rapidly degraded by the enzyme DPP-4, which limits its therapeutic use
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Some patients maintain excellent results at intermediate doses, while others benefit from reaching the 2.0 mg weekly maintenance level
