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Some individuals may also benefit from additional interventions, such as bariatric surgery

Consequently, maintaining the therapeutic effects of GLP-1R agonism requires a long-term dosing regimen, much like medications used for other chronic conditions, such as statins for cholesterol control, ACE inhibitors and beta-blockers for blood pressure, or warfarin for blood thinning

In fact, a study from the University of Queensland calls fatigue the second-most common side effect of Ozempic

So is this a case where three hormones targeted is better than two

Concerning cutaneous manifestations, specifically bullous pemphigoid, retrospective analysis of over 9,000 patients treated in Japan (20092017) associated it with DPP-IV inhibitors, particularly vildagliptin (Kawaguchi et al., 2019)