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The introduction of this new indication may have led to a broader user population, consequently resulting in a higher number of reported adverse reactions

Implications for Glucagon Family Receptor Poly-Agonists: GLP-1R Agonism Is Sine Qua Non Over the past few years, novel class B1 GPCR poly-ligands, i.e., compounds that bind more than one receptor simultaneously, have joined the ranks of the classic GLP-1RAs (GLP-1R mono-agonists), such as exenatide, liraglutide, semaglutide, dulaglutide, etc

Preprocedural diet modification with 24-hour clear fluid diet, followed by standard 6-hour fasting, should be recommended for all patients receiving GLP-1 RAs and GLP-1/GIPRAs

Additionally, if you develop symptoms suggestive of gallbladder diseasesuch as right upper abdominal pain, particularly after eating fatty foods, accompanied by nausea or jaundicecontact your GP, as rapid weight loss can increase the risk of gallstones, a warning highlighted in the MHRA safety information for GLP-1 receptor agonists

Plan care through a multidisciplinary team involving gastroenterology and obstetrics

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