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Description
That chronic inflammation drives insulin resistance, which means more fat storage and stronger cravings

This paper reviewed the adverse effects on mental health associated with past and current antiobesity drugs that act in the brain, and it explored the underlying neural and chemical reasons for these effects

For example, a recent study indicated that unlike in mouse islets where tirzepatide stimulates insulin secretion predominantly through the GLP-1R, the therapeutic effects of tirzepatide on human beta and alpha cells require engagement of both the GLP-1R and the GIPR, and in addition, tirzepatide increased glucagon secretion in isolated islets [207]

This is not a cautious hedge

These reflect genuine health improvements that the scale cannot capture

Before making any changes, however, you should talk with your healthcare provider to discuss the pros and cons of each specific medication