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Swirl the beads and water gently for at least 20 seconds

It is less effective for non-inflammatory acne, like blackheads and whiteheads, which are better treated with topical retinoids

Part 2 of ESSENCE is an open-label extension that will follow patients for up to five years, monitoring endpoints including cirrhosis-free survival, and is due to generate results in 2029

The recommendation is to take NSAIDs with whatever food you do eat, use the lowest effective dose, and consider switching to acetaminophen for pain management where possible