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7.4 Catestatin and autonomicmetabolic regulation Catestatin, a peptide derived from the prohormone chromogranin A, inhibits catecholamine release and modulates sympathetic tone

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Glucagon receptor antagonist upregulates circulating GLP-1 level by promoting intestinal L-cell proliferation and GLP-1 production in type 2 diabetes

Reduce Glucagon Secretion: Prevent excessive glucose production by the liver

While GLP-1 (7-36amide) and GLP-1 (737) are equally potent to stimulate the secretion of insulin and c-peptide [181], GLP-1 (137) has a much lower insulinotropic efficacy [[80], [81], [82]]

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