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Weight maintenance depends on continuing a healthy lifestyle

Although GLP-1 drugs typically suppress overall appetite, individuals may still notice: Sudden sweet cravings as nausea fluctuates Desire for reward foods or comforting rituals Emotional tension around eating and treats These experiences are common in community discussions and reflect how complex appetite regulation can be on GLP-1 therapy
An accompanying editorial to the study noted that if the benefit is cumulative, adding roughly three motor-score points of protection per year over 5-10 years, then this class of drugs could prove transformative for a disease that currently has few disease-modifying interventions

These cells release the recruiting chemokine CCL-2

~7% for tirzepatide in SURMOUNT-1) and a new dysesthesia signal at ~21% incidence that didn't appear in Phase 2

Semaglutide is a GLP-1 receptor agonist initially developed to treat type 2 diabetes
