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Measurable weight loss generally becomes apparent within 48 weeks of initiating tirzepatide, with the rate of loss typically accelerating as the dose is titrated upward according to the prescribing protocol

For context, NICE guidance on obesity pharmacotherapy including TA875 (semaglutide for weight management) and TA924 (tirzepatide for managing overweight and obesity) provides a useful framework for understanding how future agents might be positioned in the UK

A recent umbrella review encompassing data from 108,030 men with diabetes estimated a global pooled prevalence of 65.8% [10]

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3,4 Another agent gaining in popularity is tirzepatide (Mounjaro, Zepbound), a dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 RA