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In the landmark STEP 1 trial, which was published in The New England Journal of Medicine, the results were striking
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A reduction of FGF19 and GLP-2 disrupts this receptor signaling, leading to an imbalance between gallbladder contraction and relaxation, thus delaying bile refilling and promoting bile stasis, increasing the risk of gallstone formation due to oversaturated bile

In these situations, GLP-1 medications may be complemented by non-invasive body contouring treatments, which can help refine specific areas of concern
The Quantitative Insights Into Microbial Ecology (QIIME, v1.8.0) pipeline was employed to process the sequencing data in microbiota analysis

PMCID: PMC12502165
