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Clinical-stage obesity-related drugs targeting GLP-1R, GIPR, or GDF-8 through November 2024. Quality, Off-the-Shelf, Metabolic Pathway Proteins from KACTUS The targets involved in obesity treatment encompass various pathways that contribute to the onset and progression of the condition

Improved clinician awareness, adverse-event reporting, product-quality monitoring, digital risk communication, and proportionate regulatory oversight are needed to distinguish evidence-based peptide therapy from unregulated consumer use.