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In this review, we provide a comprehensive description of the diverse roles for GLP-1 across multiple tissues, describe downstream pathways stimulated by acute and chronic exposure, and discuss novel pleiotropic applications of GLP-1 mimetics in the treatment of human disease

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Chadchan, S

Elevated glucagon generation and release of free fatty acids triggers ketogenesis with production of ketone bodies, leading to acidosis (Figure 1)