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J Biol Chem 267(11):74027405 Schirra J, Sturm K, Leicht P, Arnold R, Goke B, Katschinski M (1998) Exendin(939)amide is an antagonist of glucagon-like peptide-1(736)amide in humans

This observation aligns with previous work showing that pharmacological inhibition or genetic ablation of NMDA receptors in agouti-related-protein (AgRP)-expressing neurons alters synaptic adaptation to fasting 39,40

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Saxena, A

In a recently published phase II study conducted on 92 T2D patients with a BMI 27 kg/m 2 , a 2.18% decrease in HbA1c and a 15.6% reduction in body weight were confirmed in the group administered CagriSema once a week [102]

The occurrence of these unfavorable outcomes can vary from 12% to 66%, depending on the substance and dosage used [73]