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What does Aetna typically want to see in a PA request for a weight loss drug
The slow adoption of anti-obesity treatments may be a spill-over of unfavorable past experiences
Therefore, a pivotal question is whether the demonstrated BBB permeability of certain GLP-1RAs translates to effective penetration of the BRB to achieve therapeutic concentrations in retinal tissues
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Given the potential loss of effectiveness in Gs signalling in diabetic conditions and that both GIP and GCG seem to primarily act through Gs signalling, it raises a second question: is the effect of triagonist on glucose-stimulated insulin secretion (GSIS) mediated solely via GLP-1R
doi: 10.1016/j.amjmed.2015.07.015
