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Humans are very bad at taking medications
PVN infusion of GLP-1-(7-36) amide suppresses feeding but does not induce aversion or alter locomotion in rats

10.1007/s10787-022-00956-6 Inflammopharmacology 4 Aviles-OlmosI.DicksonJ.KefalopoulouZ.DjamshidianA.EllP.SoderlundT.et al (2013)
Persistent metabolic adaptation 6 years after "The Biggest Loser" competition
It does not cover single-dose Zepbound vials or pens