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The abnormal signal pathways will lead to excessive production of FFAs and ROS in adipocytes and hepatocytes, which is a milestone of the first step to develop MASH (Portincasa et al., 2024)

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doi:10.1016/j.obpill.2022.100047

Disclosures Disclosure forms, as provided by each author, are available with the online version of the article at Funding None

During oral glucose ingestion, GIP(3-30)NH 2 infusion reduces postprandial splanchnic blood flow in healthy men ( 3.8 Adverse effects of GIP receptor antagonism So far, no adverse effects have been reported with the administration of GIP receptor antagonists in humans or animals

While the clinical impact varies, it is important to consider timing and dosing adjustments