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To identify phenotypes, processes, and pathways associated with metabolites related to the analyzed drugs, we performed gene enrichment analysis on the selected metabolite lists

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To a large extent, these changes are also characteristic of metabolic syndrome, which affects approximately 25% of the worlds adult population and is associated with insulin resistance, hypertension, dyslipidemia and obesity, factors that increasingly lead to cognitive impairment and brain atrophy

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None of the drugs yet have clinical trials with more than 2-year follow-up which leaves us with questions as to micronutrient deficiencies and risk of loss of muscle mass and bone density

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The North American Neuro-Ophthalmology Society and the American Academy of Ophthalmology recently provided a summary of the existing literature in an article in Ophthalmology

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[53] Treatment was given for 40 weeks to 104 weeks

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