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In combination with glimepiride, with or without metformin, the overall incidence of clinical adverse reactions with sitagliptin was higher than with placebo, in part related to a higher incidence of hypoglycemia (see Table 3)

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[1] The most frequently reported gastrointestinal side effects include: Nausea (very common, affecting more than 1 in 10 patients) Diarrhoea (very common, affecting more than 1 in 10 patients) Vomiting (common to very common, depending on dose) Decreased appetite (very common) Constipation Abdominal pain or discomfort Dyspepsia (indigestion) Belching , which may occasionally have a sulphurous odour These symptoms typically occur because GLP-1 receptor agonists slow gastric emptyingthe rate at which food leaves the stomachand alter gastrointestinal motility

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