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Rapid weight loss raises gallstone risk, and GLP-1 agonists carry cautions about pancreatitis, a modest heart-rate increase, and a rodent-based thyroid C-cell tumor signal (contraindicated with a history of medullary thyroid carcinoma or MEN 2)

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The conversation covers real world effectiveness, side effects, muscle loss concerns, cost and sustainability, and the need for GLP 1 stewardship, including minimum effective dosing, resistance training, and clear plans for tapering when appropriate

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