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It works by improving insulin resistance and allowing calories and fat to be burned while increasing energy levels

Improves Metabolic Function : By enhancing insulin sensitivity and reducing glucose levels, it lowers inflammation and contributes to better overall health

46 In patients with T2DM, the Tirzepatide versus Semaglutide once weekly in patients with T2DM (SURPASS-2) trial compared tirzepatide with semaglutide 1 mg (both as add-on therapies to metformin) and found tirzepatide was either noninferior or superior at all doses (5 mg, 10 mg 15 mg), for both HbA 1c reduction and weight loss at 40 weeks

doi: 10.1530/JOE-16-0450 8 LeeSTsirbasAGoldbergRAMcCannJD

This gap reflects a combination of limited clinician familiarity with prescribing guidelines, concerns about medication safety, and barriers to insurance coverage