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Conclusions GLP-1RAs had a neutral effect on the composite cardiovascular outcomes but reduced composite kidney events in the patients with advanced DKD compared with DPP-4is.

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This review article examines the translational evolution of glucagon-like peptide-1 receptor agonists (GLP-1RAs), tracing their progression from the discovery of exendin-4 in Gila monster venom to long-acting peptide analogues and the first orally delivered peptide therapy, oral semaglutide
