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During the initial four-week period on 0.25 mg, the medication gradually accumulates in your system until it reaches what is termed 'steady state' typically achieved after four to five weeks of consistent weekly dosing, as stated in the UK SmPC

12, ranitidine administration led to an increase in DNA alterations represented by increased tailed cells with decreased diameter of comet head, and increased DNA percentage in the tail showing oxidative actions by ranitidine on DNA

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(2026, Jan 21)