what is tirzepatide side effects vs. Semaglutide: You Should Know Tirzepatide Side Effects Timeline: When

Avoid during pregnancy or while trying to become pregnant

Key Takeaways Effectiveness: Tirzepatide may lead to greater average weight loss in trial populations

Mandatory four-week pre- and post-operative smoking cessation is essential

While metformin does cross the placenta, multiple studies and meta-analyses have not demonstrated increased risks of major congenital malformations compared to insulin therapy

Read more: Mounjaro costs in 2026: With and without insurance coverage Zepbound Private/employer-sponsored plans: Coverage is variable

Multi-dose vial handling If you are using a multi-dose vial, additional precautions apply