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In clinical trials, retatrutide achieved 24.2% weight loss at 48 weeks versus tirzepatide approximately 21% at 72 weeks, suggesting stronger overall appetite and metabolic effects

Freezing causes ice crystal formation that can damage the peptide structure, reducing potency unpredictably
The prolonged terminal half-life is thought to be due to extensive uptake and subsequent release of drug from tissues

Following proper injection techniques can help make the process smoother and more comfortable
