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3 However, gastrointestinal side effects increased with high dosage

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Common adverse effects reported in clinical trials include: Nausea (occurring in up to 29% of patients) Diarrhea (reported by up to 23% of patients) Vomiting (affecting up to 10% of patients) Constipation (experienced by up to 17% of patients) Abdominal pain and dyspepsia Decreased appetite (an intended therapeutic effect) These gastrointestinal symptoms typically occur most frequently during dose escalation and tend to diminish over time as patients develop tolerance to the medication

References Al-Kuraishy HM et al

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