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We highly encourage supplemental therapies and lifestyle changes (proper nutrition and exercise).

The search period extended from January 1990 through December 2025 to capture both foundational mechanistic research on testosterone signaling and contemporary clinical trials evaluating GLP-1 receptor agonists and testosterone replacement therapy

After deep anaesthesia with isoflurane (Attane Vet, 1,000 mg g 1 , ScanVet, Piramal Critical Care) mice were decapitated and the brain was removed and submerged in ice-cold aCSF (124 mM NaCl, 5 mM KCl, 1.2 mM Na 2 HPO 4 2H 2 O, 2.7 mM CaCl 2 2H 2 O, 1.2 mM MgSO 4 (anhydrous)), 10 mM dextrose, 26 mM NaHCO 3 was adjusted to pH 7.4 and an osmolarity of 298302 mOsm kg 1 after saturation with carbogen (95% O 2 /5% CO 2 )

Typical dosing: Daily Common side effects: Dry mouth, tingling, constipation, sleep changes Important note: Usually titrated gradually

Semaglutide Concerns: Informed Decision-Making Patients prescribed Ozempic for diabetes management or considering its off-label use for weight loss are increasingly concerned about the medications safety profile

Both medications are considered GLP-1 receptor agonists