innoviva glp-1 receptor agonist weight management diabetes treatments Agonists Explained: Definition, How They Work, Side Effects Weight Reduction with GLP-1 Agonists

Description

J., Choi, M

These medications, which mimic the functions of the naturally occurring hormone GLP-1 (glucagon-like peptide-1), have been lauded for their efficacy in not only controlling blood sugar levels but also promoting weight loss

The GLP-1 Analogue Lixisenatide Decreases Atherosclerosis in Insulin-Resistant Mice by Modulating Macrophage Phenotype

Lancet 2021;398:181124.PubMed 89

In the ongoing SURPASS-CVOT trial (ClinicalTrials.gov ID NCT04255433), the safety of tirzepatide versus GLP-1RA dulaglutide is assessed in patients living with T2DM with confirmed atherosclerotic CVD, including participants treated with insulin and SGLT2 inhibitors, where the composite primary outcome will be the time to first occurrence of MACE