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Retatrutide vs Tirzepatide Retatrutide, a first-in-class triple hormone receptor agonist targeting GLP-1, GIP, and glucagon receptors, demonstrates unprecedented weight loss efficacy in clinical trialsup to 24.2% body weight reduction at 48 weeks

Less movement means fewer calories burned, which, over time, can contribute to gradual weight gain

The brain: Psychologically, many people who are overweight or obese eat in response to negative feelings or thoughts or have binge eating tendencies

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Use with caution and discontinue if irritation occurs

Instead, the brain loses the ability to form new memories, a condition called anterograde amnesia
