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The integrated pharmacological and structural information of different GLP-1 analogs and homologous receptors give new insights into the molecular determinants of GLP-1R ligand selectivity and functional activity, thereby providing novel opportunities in the design and development of more efficacious agents to treat metabolic disorders

Understanding your natural GLP-1 activation capacity matters because it shapes realistic expectations for lifestyle-only approaches versus personalized medical support

Glutathione therapy for male infertility Adeoye, O., et al

Protein helps maintain muscle and reduces cravings, while fiber and fats keep you feeling full and help regulate blood sugar

Methods and results We employed a large animal model, the female landrace pig, and used multiple in vivo and ex vivo approaches including pharmacological challenges, electrophysiology, and high-resolution mass spectrometry to explore how GLP-1 elicits an increase in heart rate

FASEB J 2017;31:534255