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This sounds like a bit of a mixed signal in terms of some of it related to dehydration and some of it actual low blood pressure, which is the perfect segue into the cardiometabolic benefits starting with blood pressure reductions

SGLT2 inhibitors are now authorised for the treatment of chronic kidney disease and heart failure in individuals with or without T2DM [1, 2]

Patients with severe kidney disease or end-stage renal disease may not be appropriate candidates for this therapy, particularly if they have significant fluid retention or are prone to dehydration

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This approach emphasized the use of cardioprotective GLP-1 RAs [liraglutide, dulaglutide, semaglutide, and albiglutide (withdrawn from the market for business reasons)] in T2DM patients with or at high risk for atherosclerotic CVD (ASCVD), heart failure (HF), or chronic kidney disease (12)

Dual peptides for the treatment of obesity Tirzepatide, a novel dual GIP and GLP-1RA, offers significant insights into its mechanism of action, therapeutic benefits, and clinical applications for the management of T2D and obesity in general practice