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However, the comparison among GLP-1 RAs on cardiovascular outcomes is limited

That is, no physical barrier exists for gutderived GLP1 to reach the cranial circulation, but the combination of physiologically released doses and DPP4 inactivation might make it unlikely that postprandially released GLP1 reaches even the circumventricular organs of the brain

While its exact mechanism of action behind the GLP agonists and vivid dreams is unknown, Novo Nordisk has received multiple reports of bizarre dreams from patients taking semaglutide, and these reports are commonly shared on support groups and social media. Ozempic dreams are weirder or wackier than normal, and may or may not involve celebrities

An important nuance often overlooked: there is currently no robust evidence showing that monthly dosing is superior to weekly or daily regimens purely in terms of adherence
