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Most healthcare providers recommend at least 3 months of consistent treatment to fairly assess whether semaglutide is working for you

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Key examples are listed in the Sources section below the article

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Feldman, R

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Semaglutide is dosed once weekly

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Although GLP-1 medications have complex dosing schedules, you can consider switching between GLP-1 medications if you experience intolerable side effects with your current medication, do not get significant results, or due to a drug shortage

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Lilly's oral GLP-1 orforglipron consistent with injectable GLP-1 medicines owenhaskins Apr 17, 2025 3 min read The topline Phase 3 results from Eli Lilly ACHIEVE-1 study, evaluating the safety and efficacy of orforglipron compared to placebo in adults with type 2 diabetes and inadequate glycemic control with diet and exercise alone, have revealed that orforglipron met the primary endpoint of superior A1C reduction compared to placebo at 40 weeks

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