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As well as supporting weight management, they reduce the risk of cardiovascular disease and can prevent the onset of type 2 diabetes

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Combined activation of GLP-1, GIP, and GCG systems theoretically provides complementary mechanisms: GLP-1-mediated insulin sensitization and satiety promotion, GIP-mediated enhancement of insulin secretion and adipose lipid buffering, and glucagon-mediated direct hepatic lipid oxidation and energy expenditure augmentation

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Finding: Semaglutide reduced the risk of major kidney events by 24% and major cardiovascular events by 18%

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