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In his recent autobiography, "Karma," George claimed that he was hardly alone in turning to a GLP-1

Johnson B et al

These shifts create weight changes unrelated to fat loss but visible on the scale

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Notably, several of the GLP-1 RAs examined in these studies (e.g., exenatide, lixisenatide) are gradually being retired from clinical use, while the therapeutic landscape is shifting toward newer GLP-1 RAs (e.g., semaglutide) and dual-or triple-agonist compounds (e.g., tirzepatide, retatrutide)