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Often referred to as the 'satiety hormone', leptin signals to the brainspecifically the hypothalamuswhen the body has sufficient energy stores, thereby reducing appetite and increasing energy expenditure

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An orthogonal protecting group approach was employed, where all Dab side chain amines were protected as Boc, threonine as tBu, and the amino group of Dab involved in the cyclization was protected as Alloc

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