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Evidence for separate roles Several lines of evidence support the notion of distinct roles for peripheral and central GLP-1 in appetite regulation: Differential breakdown: Peripheral GLP-1 has a very short half-life in the blood (around two minutes) due to enzymatic degradation

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Until that data becomes available, the Phase 2 results showing no thyroid safety signals, combined with the broader class experience, suggest the thyroid concern does not materially differ between GLP-1 medications

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Many issues impact which treatment option a patient may choose

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Set realistic expectations: Celebrate small milestones rather than focusing solely on the scale

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