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A Phase 2 trial by Metabolic Pharmaceuticals found that while the compound was well-tolerated, it did not produce statistically significant weight loss versus placebo at the doses tested

Clinical Evidence for Alli as a Weight Loss Aid The clinical evidence supporting orlistat as a weight loss aid is well established

The letter was published by industry stalwart Quirks Magazine and is available HERE
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However, practical considerations exist regarding gastrointestinal tolerability
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