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26 They are generally mild, nondisabling, and most frequently occur within the first 26 weeks of treatment

Although 25mg is the recommended maintenance dose associated with the best results, some people may find they get good appetite suppression, feel fuller for longer, and achieve worthwhile weight loss on a lower dose

Behind this leap in ranking are the strong performances of the twin stars, Mounjaro (Tirzepatide) and Zepbound (Tirzepatide)

The muscle preservation piece is the one I care about most

That extra pathway is one reason researchers are interested in retatrutide, but it is also a reason not to assume its risk profile is identical to tirzepatides